Genome scan of glomerular filtration rate and albuminuria: the HyperGEN study
نویسندگان
چکیده
منابع مشابه
Genome scan of glomerular filtration rate and albuminuria: the HyperGEN study.
BACKGROUND Albuminuria and reduced glomerular filtration rate (GFR) are markers of renal dysfunction associated with hypertension. We performed genome-wide scans to detect loci impacting these parameters in 1251 African American (AAs) and 1129 European American (EAs) hypertensive siblings from the Hypertension Genetic Epidemiology Network study. METHODS GFR, estimated by the Modification of D...
متن کاملLumping, splitting and mapping: assessing linkage in different ethnic groups for albuminuria and glomerular filtration rate in the HyperGen study.
The ability to map genes that predispose to complex disease has been an ongoing area of research for more than a decade, but results have often been less than satisfying in terms of discovering genes of major importance. One likely reason is that the phenotypes used in many linkage analyses have heterogeneous genetic causes, so that different loci may confer susceptibility in different families...
متن کاملAssociation of bone mineral density with albuminuria and estimated glomerular filtration rate: the Dong-gu Study.
BACKGROUND Kidney dysfunction and albuminuria may be associated with BMD. However, little evidence has been reported on relationships between BMD and eGFR and albuminuria. METHODS A total of 8,992 subjects aged 50 years or older participated in a survey conducted. Participants had their lumbar spine and femoral neck BMD measured by a Lunar Prodigy bone densitometer (GE, Madison, WI). Kidney f...
متن کاملGlomerular filtration rate, albuminuria, and risk of cardiovascular and all-cause mortality in the US population.
Decreased glomerular filtration rate (GFR) and albuminuria are used in combination to define chronic kidney disease, but their separate and combined effects on cardiovascular and all-cause mortality have not been studied in the general population. The linked mortality file of the Third National Health and Nutrition Examination Survey includes data from 13 years of follow-up (1988-2000) for 14,5...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2007
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfl674